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In this essential episode, Dr. Andrew Huberman explores groundbreaking mindset research with Stanford psychologist Dr. Alia Crum, revealing how our core beliefs about domains like stress, food, and exercise directly shape our physiological responses. Through fascinating studies—including the famous milkshake experiment (05:15) where participants' hunger hormones responded based on what they *believed* they were consuming—Dr. Crum demonstrates that mindsets act as powerful portals between conscious thought and subconscious bodily processes. The conversation delivers a revolutionary framework for leveraging stress as enhancement rather than detriment (23:54), complete with practical three-step approach: acknowledge the stress, welcome it as a signal of caring, and harness its physiological superpowers to achieve what matters most.
Professor of neurobiology and ophthalmology at Stanford School of Medicine, creator of the Huberman Lab podcast which has reached millions of listeners worldwide. His research focuses on neural plasticity, stress, and performance optimization.
Professor at Stanford University and director of the Stanford Mind & Body Lab. Her groundbreaking research on mindset effects has been published in top-tier journals and demonstrates how beliefs about stress, food, and exercise can directly influence physiological outcomes and performance.
Your body responds physiologically to what you believe you're eating, not just the actual nutrients. When people thought they consumed a high-calorie "indulgent" milkshake, their hunger hormone ghrelin dropped threefold compared to believing it was a "diet" shake—even though both were identical. (09:03) Stop labeling nutritious foods as "sensible" or "depriving"—instead, view healthy eating as giving yourself exactly what you need to perform at your peak.
Hotel housekeepers who were told their daily work activities constituted good exercise lost weight and reduced blood pressure by 10 points within four weeks—without changing their behavior. (15:12) Audit your daily activities: walking to meetings, taking stairs, even carrying groceries can become "workouts" when you consciously recognize them as beneficial physical activity.
Adopt a three-step approach: acknowledge you're stressed, welcome it as a sign you care deeply about something meaningful, then channel that stress response to achieve your goal rather than eliminate it. (34:15) The stress response narrows focus, speeds information processing, and can trigger anabolic hormone release—treat it as a superpower, not a liability.
Mindsets are simplifying belief systems about domains like intelligence, food, or stress that shape expectations and guide behavior. (00:40) Regularly audit your default assumptions: Do you believe abilities are fixed or malleable? Is stress enhancing or debilitating? These core beliefs become self-fulfilling prophecies that influence both motivation and physiology.
When patients view side effects as evidence their treatment is working (rather than harmful), outcomes improve significantly. (37:38) Apply this beyond healthcare: frame temporary discomfort during skill acquisition as proof of neural rewiring, or muscle soreness as confirmation of strength gains—your interpretation shapes your physiological response.
No specific statistics were provided in this episode.