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This Week in Startups
This Week in Startups•January 29, 2026

How decriminalization led to an explosion in cannabis startups (Feat. Ford Smith, Andrew Duffy, and Socrates Rosenfeld) | E2241

A roundtable discussion with cannabis industry founders explores the evolving regulatory landscape, market challenges, potency concerns, and the potential for federal legalization of cannabis.
Startup Founders
Venture Capital
B2B SaaS Business
Cannabis Business
Jason Calacanis
Socrates Rosenfeld
Ford Smith
Andrew Duffy

Summary Sections

  • Podcast Summary
  • Speakers
  • Key Takeaways
  • Statistics & Facts
  • Compelling StoriesPremium
  • Thought-Provoking QuotesPremium
  • Strategies & FrameworksPremium
  • Similar StrategiesPlus
  • Additional ContextPremium
  • Key Takeaways TablePlus
  • Critical AnalysisPlus
  • Books & Articles MentionedPlus
  • Products, Tools & Software MentionedPlus
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Timestamps are as accurate as they can be but may be slightly off. We encourage you to listen to the full context.

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Podcast Summary

This episode features TWiST's first Cannabis Roundtable with Jason Calacanis and three industry leaders: Ford Smith (UltraNative), Andrew Duffy (Sparkplug), and Socrates Rosenfeld (Jane). The discussion explores the cannabis industry's growth from $3 billion to $30 billion over the past decade, driven by state-by-state legalization and changing consumer preferences. (02:50)

  • Main themes include regulatory challenges, the impact of rescheduling from Schedule I to Schedule III, high potency products and safety concerns, taxation burdens like 280E, and cannabis displacing alcohol consumption among Gen Z.

Speakers

Ford Smith

Ford Smith is the CEO and founder of UltraNative, a cannabis-focused venture capital firm. He also runs Noble Pacific, a cannabis oil manufacturing company, and serves as an advisor to Cann, a cannabis beverage brand. Ford has been active in the cannabis industry since 2014, initially focusing on California's state-regulated market before pivoting to understand the complexities of hemp versus cannabis regulations.

Andrew Duffy

Andrew Duffy is the CEO and founder of Sparkplug, an enterprise software platform that helps retailers incentivize employees through brand partnerships. He went through Launch Accelerator Cohort 20 and initially focused on cannabis retail before expanding into other verticals like outdoor gear, beauty, and specialty nutrition. His platform enables retail employees to earn significant additional income through commission-based product recommendations.

Socrates Rosenfeld

Socrates Rosenfeld is the CEO and founder of Jane (iHeartJane.com), a cannabis product marketplace that digitizes brick-and-mortar cannabis retail inventory. He's a military veteran who left McKinsey in 2015-2016 to enter the cannabis industry full-time. His platform creates turnkey digital storefronts for cannabis retailers, building what he calls "the Amazon for Main Street" in the cannabis space.

Key Takeaways

Federal Rescheduling Creates Historic Bipartisan Opportunity

For the first time, both Trump and Biden administrations have expressed support for rescheduling cannabis from Schedule I to Schedule III, representing unprecedented bipartisan momentum. (18:37) Andrew Duffy notes that over 70% of Americans support cannabis legalization in some capacity, crossing traditional party lines around issues of personal liberty, economics, and medical access. This regulatory shift would eliminate the devastating 280E tax burden that forces cannabis companies to pay effective tax rates of 70%, making them profitable overnight and creating massive investment opportunities for businesses that have survived the current punitive framework.

Hemp Market Loophole Revolutionizing Cannabis Business Models

The 2018 Farm Bill created an unexpected arbitrage opportunity by legalizing hemp (cannabis with less than 0.3% THC by dry weight) while keeping cannabis federally illegal. (10:00) Entrepreneurs discovered they could extract THC from hemp, concentrate it, and infuse it into products at the same potency levels as state-regulated cannabis, but without the taxation and advertising restrictions. This allows hemp-based cannabis companies to ship direct-to-consumer nationwide, run normal CPG advertising on Meta and Snapchat, and operate with significantly better margins than state-regulated competitors.

Cannabis Disrupting Alcohol Among Younger Consumers

Alcohol consumption has dropped dramatically to 54% among Gen Z compared to 70% in previous generations, with cannabis emerging as the primary substitute. (28:04) Total Wine reports that 30% of their new customers are specifically seeking THC beverages and leaving without purchasing alcohol. This shift is driven by perceptions of cannabis as healthier, lacking calories, and providing different social experiences. The trend represents a fundamental generational change that's creating massive headwinds for the alcohol industry while opening opportunities for cannabis beverage companies.

High Potency Products Result from Prohibition Economics

The prevalence of extremely high-potency cannabis products (like 400mg edibles or 80-100% THC concentrates) stems directly from prohibition and heavy taxation, not consumer preference for dangerous products. (37:41) When consumers face high costs and legal risks, they seek maximum potency per dollar spent, similar to how prohibition era drinkers chose moonshine over beer. Socrates Rosenfeld compares this to wine purchasing - no one buys wine based solely on alcohol content, but prohibition creates artificial market incentives. Proper regulation and taxation would naturally shift the market toward lower-dose, higher-quality products as the customer base expands beyond heavy users.

Industry Self-Regulation Emerging Due to Regulatory Gaps

The fragmented state-by-state regulatory approach has created dangerous gaps in product safety, with 70% of top cannabis brands in California failing pesticide tests in an LA Times investigation. (46:43) Ford Smith helped create ECHO Certified, a nonprofit industry organization that audits the top 30 California cannabis brands for pesticides and heavy metals that state regulators fail to monitor. This self-regulation model shows how responsible operators are filling regulatory voids, but it also highlights the urgent need for federal oversight to ensure consumer safety and product consistency across the industry.

Statistics & Facts

  1. The cannabis industry has grown from $3 billion to $30 billion over the past decade, representing an order of magnitude increase primarily driven by state-by-state legalization. (05:43) This growth demonstrates the massive market potential as more population centers like New York and California come online.
  2. Cannabis companies face effective tax rates of 70% due to IRS tax code 280E, which prevents them from deducting most business expenses. (32:05) This creates an enormous competitive disadvantage compared to other industries and makes profitability extremely difficult.
  3. Alcohol consumption among Gen Z has dropped to 54% compared to 70% in previous generations, with cannabis consumption emerging as the primary substitute. (30:04) This represents a fundamental shift in substance preferences among younger consumers.

Compelling Stories

Available with a Premium subscription

Thought-Provoking Quotes

Available with a Premium subscription

Strategies & Frameworks

Available with a Premium subscription

Similar Strategies

Available with a Plus subscription

Additional Context

Available with a Premium subscription

Key Takeaways Table

Available with a Plus subscription

Critical Analysis

Available with a Plus subscription

Books & Articles Mentioned

Available with a Plus subscription

Products, Tools & Software Mentioned

Available with a Plus subscription

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