Search for a command to run...

Timestamps are as accurate as they can be but may be slightly off. We encourage you to listen to the full context.
In this episode of This Week in Startups, Jason Calacanis and Alex Wilhelm explore the rapidly evolving AI landscape, examining the recent releases of Grok 4.1 from xAI and Gemini 3 Pro from Google. (00:00) The hosts discuss how these powerful new models might counter the growing AI skepticism and "doomerism" that has characterized recent months. (17:29) They also dive into Cloudflare's significant downtime and its acquisition of Replicate, while addressing the broader implications of cloud service dependencies for startups.
Jason is a prominent startup investor and the founder of Launch, which includes the Twist500 list and Founder University accelerator program. He previously built and sold Weblogs, Inc. and has been a leading voice in the startup ecosystem for over two decades, known for his early investments in companies like Uber.
Alex is a seasoned technology journalist and startup analyst who covers emerging trends in artificial intelligence, venture capital, and startup markets. He regularly provides data-driven insights on AI developments and market dynamics on This Week in Startups.
Jason emphasizes that startups should consider running their own AI models using open-source alternatives rather than feeding proprietary data into third-party systems. (08:12) He uses the example of a hypothetical building codes startup that spends $10 million hiring 100 researchers to collect and normalize data - if they then feed this into ChatGPT or Claude, those companies learn from their investment. The key insight is that companies need to weigh the convenience of API calls against the long-term competitive risk of training their competitors. Jason notes that 80% of Andreessen Horowitz portfolio companies are already experimenting with open-source models from China like DeepSeek, suggesting this trend is already underway.
The Cloudflare outage that affected major services like ChatGPT and X demonstrates how centralized dependencies can create widespread disruption. (02:01) Alex notes that if your service goes down alongside everyone else's due to a provider issue, customers tend to be more forgiving than if it's an isolated incident. However, Jason warns that if downtime extends from morning into afternoon, customers start looking for alternatives. The takeaway for founders is to understand their infrastructure dependencies and have communication strategies ready for when things inevitably go wrong.
The emergence of AI model leaderboards like LLM Arena has created healthy competition among AI labs, with both Grok 4.1 and Gemini 3 Pro recently claiming top spots. (17:08) However, Jason raises concerns about whether optimizing for benchmarks actually translates to solving real-world problems, comparing it to students mastering SATs rather than gaining practical knowledge. (18:15) The key insight is that while competition drives progress, founders and users should focus on real-world performance rather than benchmark scores when selecting AI tools.
Anthropic CEO Dario Amodei's warning about 10-20% unemployment among entry-level white-collar workers in the next 1-5 years represents a stark reality check. (35:22) Jason explains that senior professionals can now use AI to do the grunt work typically assigned to junior staff, eliminating the need for mentoring relationships that slow down productivity. The unemployment rate for 16-24 year olds is already at 10%, making this prediction particularly concerning. (37:17) Jason's advice to young people is blunt: "You're on your own. Nobody's coming to help you." The key takeaway is that individuals must proactively learn AI tools to remain employable rather than waiting for systemic solutions.
Jason predicts that future Mac computers (around the M10 generation) will have sufficient processing power and RAM to run language models locally. (12:48) This shift toward local processing would address privacy concerns while providing the kind of deep system integration that Apple is known for. He envisions a future where your computer can search through your photos, emails, and other personal data without sending anything to the cloud. This represents a fundamental shift from the current API-based model toward truly private, personalized AI assistants that understand your complete digital context.