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In this revealing conversation, world-renowned cardiologist Dr. Pradeep Jamnadas, who has treated over 250,000 patients with chronic heart disease, shares groundbreaking insights into preventing cardiovascular disease through lifestyle changes rather than relying solely on surgical interventions. (03:00) Dr. Jamnadas explains how heart disease has become increasingly prevalent in younger demographics, with inflammation being the root cause of most cardiovascular problems. The discussion covers the critical relationship between insulin resistance, visceral fat, and heart disease, emphasizing how modern eating patterns and processed foods create a perfect storm for cardiovascular complications. (24:00) The episode also explores the powerful role of intermittent fasting in reversing metabolic dysfunction, the importance of gut health for cardiovascular wellness, and practical strategies for optimizing heart health through nutrition, exercise, and lifestyle modifications.
Dr. Pradeep Jamnadas is a world-leading cardiologist with over 35 years of experience who has performed interventional procedures on more than 30,000 hearts and treated over 250,000 patients with chronic heart disease. He operates a prevention-focused cardiology practice and has gained significant recognition through his educational YouTube channel, which has nearly one million subscribers, where he makes complex cardiovascular concepts accessible to the general public.
Steven Bartlett is the host of The Diary of a CEO podcast and a successful entrepreneur and investor. At 33 years old, he has built multiple companies and is passionate about health optimization, having previously discussed topics related to ketosis and metabolic health on his platform.
Contrary to popular belief, most heart attacks occur when minor plaques rupture due to inflammation, not from large blockages that gradually close arteries. (05:46) Dr. Jamnadas explains that only 20% of patients with significant blockages actually experience chest pain, meaning many people can have dangerous arterial blockages without symptoms. The real danger comes when inflammation causes these smaller plaques to crack open, triggering blood clots that completely shut down arteries. This understanding shifts the focus from simply detecting blockages to addressing the underlying inflammatory processes that make plaques unstable.
The protruding belly fat that accumulates around internal organs (visceral fat) is fundamentally different from fat stored elsewhere in the body and poses serious cardiovascular risks. (21:42) Unlike subcutaneous fat, visceral fat produces inflammatory molecules like interleukin-6 and tumor necrosis factor, creating chronic systemic inflammation. Dr. Jamnadas can identify patients at risk simply by observing their body shape - those with prominent belly fat while appearing relatively normal from behind typically have hyperinsulinemia and are at high risk for cardiovascular disease.
When fasting for 12+ hours, the body preferentially burns visceral fat first, making it far more effective than simple calorie restriction for cardiovascular health. (21:30) Dr. Jamnadas explains that fasting creates a completely different physiology than calorie restriction - while calorie restriction slows metabolism and can break down muscle tissue, fasting preserves muscle while specifically targeting the most dangerous inflammatory fat around organs. This approach also triggers beneficial processes like autophagy, stem cell production, and improved insulin sensitivity.
A dysfunctional gut microbiome directly contributes to cardiovascular disease through multiple pathways, making gut health essential for heart health. (45:30) When the gut lining becomes compromised (leaky gut), bacterial toxins enter the bloodstream and cause fatty liver, systemic inflammation, and ultimately cardiovascular disease. Dr. Jamnadas has found that patients with chronic constipation or poor bowel health often develop significant coronary calcium deposits, and addressing gut health can stop the progression of cardiovascular disease.
Environmental toxins including mold (found in 70% of homes), pesticides, heavy metals, and processed foods work synergistically to create chronic inflammation that drives cardiovascular disease. (59:52) Dr. Jamnadas emphasizes that these toxins overwhelm the body's natural detoxification systems, particularly the liver, creating sustained inflammatory states. Even seemingly healthy choices like excessive fruit consumption or improperly prepared rice can contribute to metabolic dysfunction and cardiovascular risk through their effects on insulin and inflammation.