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In this episode, Keller Clifton, co-founder and CEO of Zipline, discusses how the drone delivery company has revolutionized medical logistics across eight countries and is now expanding to suburban American deliveries. Starting in Rwanda with medical deliveries in 2014, Zipline has completed over 100 million autonomous flight miles with zero safety incidents, serving 5,000 hospitals and health facilities. (02:36) The company now operates in suburban America, delivering everything from Chipotle burritos to Walmart orders through their Platform Two system, which uses vertical takeoff drones that hover 300 feet above homes and lower packages via precision-controlled droids. (40:52)
Keller Clifton is the co-founder and CEO of Zipline, the world's largest commercial autonomous drone delivery system. A former professional rock climber who studied biochemistry and computer science at Harvard, Clifton pivoted from a previous robotics startup to launch Zipline in 2014. Under his leadership, the company has achieved over 120 million commercial autonomous flight miles with zero safety incidents, serving 5,000 hospitals across eight countries and demonstrating a 51% reduction in maternal mortality in Rwanda.
Clifton emphasizes that none of Zipline's customers care about drones - they want "teleportation" that solves real problems. (06:46) Whether it's ministries of health, Walmart, or Cleveland Clinic, customers don't want to manage fleets of autonomous aircraft; they want reliable point-A-to-point-B solutions that save lives or transform customer experiences. This customer-first approach helped Zipline avoid the common trap of building impressive technology demos that don't address genuine market needs. The lesson: lead with customer pain points, not technological capabilities.
Despite having ambitious visions for complex vertical takeoff systems, Zipline initially built the simplest possible solution - a basic fixed-wing drone dropping packages with parachutes. (39:36) This "embarrassing" first version scaled to serve 5,000 hospitals because it solved the core problem. Clifton advocates forcing yourself into the real world quickly rather than perfecting technology in R&D labs. (73:44) Even after nine months of "disasters," this practical approach led to breakthrough success.
Zipline succeeded by partnering with Rwanda, a country "as desperate as we were as a startup" to prove transformative technology. (09:03) They needed a national healthcare system willing to take entrepreneurial risks rather than fragmented private systems. This strategy of finding forward-leaning partners who are "100% aggressively courting new solutions" (60:14) enabled rapid deployment and iteration. The key is identifying organizations facing urgent problems that make them willing to embrace unproven but promising solutions.
Zipline learned that production reliability requires obsessive attention to mundane details. Early aircraft had 43 different types of fasteners, making maintenance logistics nightmarish across multiple distribution centers. (32:00) The next iteration used only two types of fasteners. Similarly, they moved GPS from flight computers to batteries to eliminate 20-minute satellite acquisition delays during emergency deliveries. (31:35) These "unfancy but hard to learn" operational improvements were crucial for scaling from serving one hospital to 5,000 facilities.
Zipline designs 43 major subassemblies from scratch, including custom servos, because existing components couldn't meet their automotive-grade cost and reliability requirements. (33:45) Their South San Francisco facility co-locates engineering with manufacturing to enable rapid iteration - engineers work directly with production teams to implement hardware changes quickly. (61:52) This vertical integration philosophy allows them to release software updates to their global fleet every 30 days, compared to Boeing's three-year cycle for critical fixes. (64:50)