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This Week in Startups
This Week in Startups•November 22, 2025

Jason predicts a “major M&A moment” in the next six months! | E2213

Jason predicts a major M&A moment in the next six months, with potential mergers or acquisitions involving mid-cap companies like Airbnb, Uber, or Coinbase.
Creator Economy
AI & Machine Learning
Tech Policy & Ethics
Developer Culture
Web3 & Crypto
Sam Altman
Jensen Huang
Jason Calacanis

Summary Sections

  • Podcast Summary
  • Speakers
  • Key Takeaways
  • Statistics & Facts
  • Compelling StoriesPremium
  • Thought-Provoking QuotesPremium
  • Strategies & FrameworksPremium
  • Similar StrategiesPlus
  • Additional ContextPremium
  • Key Takeaways TablePlus
  • Critical AnalysisPlus
  • Books & Articles MentionedPlus
  • Products, Tools & Software MentionedPlus
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Timestamps are as accurate as they can be but may be slightly off. We encourage you to listen to the full context.

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Podcast Summary

In this episode of This Week in Startups, Jason Calacanis broadcasts from Las Vegas while attending F1, joined by co-host Alex Wilhelm to discuss the latest developments in AI, M&A predictions, and market trends. (01:54) The hosts dive deep into Nvidia's recent earnings results, analyzing the implications for the AI industry and addressing Michael Burry's controversial claims about GPU depreciation fraud. (11:39) A major revelation emerges about Google's surprising dominance in consumer AI adoption, with Gemini now potentially surpassing ChatGPT in user numbers. (19:52) The episode also showcases an impressive demonstration of Google's new AI image generation capabilities and concludes with Jason's bold prediction about a major M&A wave coming in 2025.

  • Main themes: AI market dynamics shifting toward Google's favor, concerns about job displacement from improving AI capabilities, and anticipated M&A activity in the tech sector driven by regulatory changes

Speakers

Jason Calacanis

Angel investor, entrepreneur, and founder of Launch, Jason has been a prominent voice in the startup ecosystem for nearly two decades. He's known for his early investments in companies like Uber and his role in creating successful accelerator programs, including the expansion of Founder University to global markets like Saudi Arabia and Japan.

Alex Wilhelm

Tech journalist and co-host who brings analytical depth to startup and tech industry discussions. Alex provides detailed market analysis and data interpretation, particularly around AI company valuations and market dynamics.

Key Takeaways

Focus on Core Competencies to Avoid Competitive Disadvantage

Jason emphasizes that successful companies must concentrate resources on their primary value proposition rather than getting distracted by peripheral activities. (43:20) Using the MySpace vs Facebook example, he explains how MySpace failed because they were dealing with server infrastructure and corporate politics while Zuckerberg focused solely on growth and product improvement. This principle applies to modern startups facing AI disruption - companies that spend time on non-core activities like fundraising and infrastructure management will lose to competitors who can dedicate more resources to product development. The key insight is that operational efficiency and focus become exponentially more valuable when facing well-resourced competitors.

Leverage Global Market Opportunities Through Proven Business Models

The discussion about restaurant expansion across global markets reveals a crucial strategy for modern entrepreneurs. (03:26) Jason observes how premium restaurants like Carbone successfully replicate their experience in Dubai, Saudi Arabia, and Las Vegas by maintaining consistent quality while adapting to local preferences. For entrepreneurs, this demonstrates that once you perfect a product or service in one market, global expansion becomes more feasible due to increasingly similar consumer preferences worldwide. The practical application is to build something exceptional locally first, then systematically expand to similar markets rather than trying to be everything to everyone from the start.

Prepare for Accelerated Job Displacement Through AI Advancement

The demonstration of Google's AI creating professional-quality infographics in seconds illustrates the rapid pace of AI capabilities replacing human work. (38:29) Jason points out that what previously required a $60,000-70,000 annual graphic designer and a week of work can now be accomplished instantly. Rather than being doom and gloom, this serves as a wake-up call for professionals to upskill and focus on uniquely human capabilities. The strategic response should be curiosity about emerging tools combined with concern about maintaining relevance, leading to proactive skill development in areas that complement rather than compete with AI.

Build Agentic Workflows to Stay Relevant in the AI Era

For software engineers specifically, Jason recommends focusing on creating agents that automate organizational chores and repetitive tasks. (52:02) He describes the need for systems that run automatically on schedules to handle routine work in departments like customer support, sales, and operations. This involves studying existing workflows within organizations and identifying opportunities for automation. Engineers should develop skills in creating systems that make companies more efficient and "lean, mean fighting machines" rather than trying to compete with AI in areas where it excels.

Capitalize on Emerging M&A Opportunities Through Strategic Positioning

Jason predicts a major M&A wave in the next six months, driven by recent regulatory wins for big tech companies and favorable market conditions. (50:36) He specifically forecasts that companies valued between $25-250 billion will become acquisition targets, citing examples like potential Amazon-DoorDash or Uber-related consolidations. For entrepreneurs and investors, this suggests positioning portfolio companies or personal investments to benefit from consolidation trends. The strategy involves identifying companies that could provide strategic value to larger players, particularly in areas like autonomous vehicles, delivery services, or productivity tools where scale advantages are significant.

Statistics & Facts

  1. Google's Gemini AI products now reach approximately 2.65 billion users monthly, with 2 billion using AI overviews in search and 650 million using the Gemini mobile app, potentially surpassing ChatGPT's 800 million weekly users. (22:12)
  2. OpenAI expects to reach $20 billion in annualized revenue by the end of 2025, despite facing increased competition from multiple AI providers. (24:15)
  3. Kalshi raised $30 million at a $5 billion valuation in October and is now reportedly raising $800 million at an $11 billion valuation, with combined Kalshi and Polymarket trading volume growing from $2 billion to $7.5 billion between August and October. (46:28)

Compelling Stories

Available with a Premium subscription

Thought-Provoking Quotes

Available with a Premium subscription

Strategies & Frameworks

Available with a Premium subscription

Similar Strategies

Available with a Plus subscription

Additional Context

Available with a Premium subscription

Key Takeaways Table

Available with a Plus subscription

Critical Analysis

Available with a Plus subscription

Books & Articles Mentioned

Available with a Plus subscription

Products, Tools & Software Mentioned

Available with a Plus subscription

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