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a16z Podcast
a16z Podcast•September 8, 2025

The Little Tech Agenda for AI

In this episode of the a16z Podcast, Matt Perrault and Colin McHugh discuss the "Little Tech Agenda" for AI policy, advocating for a regulatory approach that focuses on harmful use rather than development, and ensures startups can compete in the AI landscape while maintaining national technological leadership.
AI & Machine Learning
Tech Policy & Ethics
Developer Culture
Mark Andreessen
Ben Horowitz
Matt Perrault
Colin McHugh
Meta

Summary Sections

  • Podcast Summary
  • Speakers
  • Key Takeaways
  • Compelling StoriesPremium
  • Strategies & FrameworksPremium
  • Thought-Provoking QuotesPremium
  • Statistics & Facts
  • Additional ContextPremium
  • Key Takeaways TablePlus
  • Critical AnalysisPlus
  • Similar StrategiesPlus
  • Books & Articles MentionedPlus
  • Products, Tools & Software MentionedPlus
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Timestamps are as accurate as they can be but may be slightly off. We encourage you to listen to the full context.

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Podcast Summary

In this comprehensive episode, Colin McHugh and Matt Perrault from a16z dive deep into the "Little Tech Agenda" - their strategic framework designed to ensure AI regulation works for scrappy five-person startups, not just tech giants. They trace the evolution from early existential AI fears (10:45) that nearly led to nuclear-style licensing regimes, to today's more balanced approach emphasizing federal preemption and the core principle: regulate harmful use, not development (09:05). The duo explores why current state-level patchwork regulations create impossible compliance burdens for resource-constrained founders, while offering a roadmap for smart governance that protects consumers without stifling the very competition needed to prevent AI monopolization.

Speakers

Matt Perrault

Head of AI Policy at Andreessen Horowitz (a16z), former Meta policy executive (2011-2019) who worked through the intense tech regulation debates post-2016. He leads a16z's "regulate use, not development" framework and advocates for smart AI governance that protects consumers while enabling startup competition.

Colin McHugh

Head of Government Affairs at a16z, architect of the Little Tech Agenda focused on representing startups in Washington DC policy debates. He leads coalition-building efforts and political advocacy to ensure AI regulation doesn't favor only trillion-dollar companies with massive compliance teams over five-person garage startups.

Host

The a16z podcast host facilitates discussions on technology policy and startup advocacy. The show explores how regulation impacts innovation and competition in emerging tech sectors.

Key Takeaways

Build Your Political Infrastructure Before You Need It

The moratorium's failure revealed that "the industry was just not organized well enough." Startups can't afford to wait until crisis hits—establish relationships with policymakers, build coalitions, and create advocacy channels during peacetime. (45:00) The most successful policy outcomes emerge from sustained engagement, not last-minute scrambling.

Master the "Regulate Use, Not Development" Framework

Position yourself as pro-smart regulation by advocating for enforcement of existing laws (consumer protection, civil rights, criminal statutes) rather than licensing regimes or development restrictions. (09:05) This approach protects against harmful AI applications while preserving the ability for startups to innovate and compete without crushing compliance costs.

Differentiate Your Voice from Big Tech

Avoid getting lumped into the "industry agrees" narrative by articulating your unique startup perspective. (55:41) When policymakers say "industry already agreed," push back with specific examples of how proposed regulations create disproportionate burdens for five-person teams versus trillion-dollar compliance departments.

Focus Policy Advocacy on Constitutional Lanes

Champion federal preemption for AI development standards while supporting state enforcement of harmful use within their borders. (47:07) This division leverages constitutional commerce clause protections and prevents the startup-killing "50-state patchwork" of conflicting regulations that only large companies can navigate.

Transform Crisis Narratives into Competitive Advantage

Reframe the "AI safety" debate from existential risk to competitive positioning against China. (38:38) Emphasize that overly restrictive policies hand technological leadership to adversaries while smart regulation can maintain both safety and American dominance in the global AI race.

Compelling Stories

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Strategies & Frameworks

Available with a Premium subscription

Thought-Provoking Quotes

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Statistics & Facts

  1. Nuclear policy in the United States has yielded only two to three new nuclear power plants in a fifty-year period since these organizations were started. (18:45)
  2. 99.9% of people that policy advocates talk to think that all they want is no regulation, despite writing extensively about the importance of good governance. (08:14)
  3. The effective altruist community, backed by large sums of money, has had a ten-year head start in influencing think tanks and nonprofit organizations in DC and state capitals to push people in a direction where they are very fearful about AI technology. (12:42)

Additional Context

Available with a Premium subscription

Key Takeaways Table

Available with a Plus subscription

Critical Analysis

Available with a Plus subscription

Similar Strategies

Available with a Plus subscription

Books & Articles Mentioned

Available with a Plus subscription

Products, Tools & Software Mentioned

Available with a Plus subscription

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